Document Detail

Biosynthesis of polyhydroxyalkanoate copolyester containing cyclohexyl groups by Pseudomonas oleovorans.
MedLine Citation:
PMID:  11589966     Owner:  NLM     Status:  MEDLINE    
Production of polyhydroxyalkanoates (PHAs) substituted with cyclohexyl groups by Pseudomonas oleovorans grown with 4-cyclohexylbutyric acid (4-CHB) and its mixtures with nonanoic acid (NA) was investigated. Addition of NA to medium gave rise to an increase in the total concentration of 3-hydroxy-4-cyclohexylbutyrate repeating unit in the PHAs, indicating that the bioconversion rate of 4-CHB to polyester was significantly improved by the cometabolic effect. Increasing the proportion of NA from 1.0 to 7.5 mM at a concentration of 10 mM total carbon substrate also accelerated the uptake speed of 4-CHB by the organism and resulted in an increase of the ratio of 3-hydroxynonanoate to 3-hydroxyheptanoate from 1.28 to 2.05. Differential scanning calorimetric analysis of the PHAs bearing the corresponding functional groups showed one melting transition and one glass transition temperature varying according to the composition. These results indicated that random copolyesters were obtained from the carbon substrates used in this study.
D Y Kim; S B Jung; G G Choi; Y B Kim; Y H Rhee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  29     ISSN:  0141-8130     ISO Abbreviation:  Int. J. Biol. Macromol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-08     Completed Date:  2002-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  England    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Department of Microbiology, Chungnam National University, Daejon 305-764, South Korea.
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MeSH Terms
Butyric Acid / pharmacology
Carbon / chemistry
Carboxylic Acids / chemistry,  metabolism*
Fatty Acids / pharmacology
Polymers / chemistry*,  metabolism*
Pseudomonas / growth & development,  metabolism*
Time Factors
Reg. No./Substance:
0/Carboxylic Acids; 0/Fatty Acids; 0/Polymers; 107-92-6/Butyric Acid; 112-05-0/pelargonic acid; 7440-44-0/Carbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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