Document Detail


BIOSYNTHESIS OF MYCOBACILLIN, A NEW ANTIFUNGAL PEPTIDE. I. ROLE OF NUCLEIC ACID.
MedLine Citation:
PMID:  14188719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Banerjee, Arun B. (University of Calcutta, Calcutta, India), and S. K. Bose. Biosynthesis of mycobacillin, a new antifungal peptide. I. Role of nucleic acid. J. Bacteriol. 87:1397-1401. 1964.-The biosynthesis of mycobacillin, a cyclic polypeptide antifungal antibiotic, was studied in relation to the effect of chloramphenicol, 6-azathymine, and 5-bromouracil on the process. It was found that chloramphenicol inhibits both mycobacillin synthesis and growth, whereas nucleic acid base analogues inhibit only growth and nucleic acid synthesis but not mycobacillin formation. A change in the concentration of labeled aspartic acid in the general metabolic pool led to a corresponding change in the specific activity of aspartic acid isolated from different peptide fragments of the mycobacillin molecule, suggesting that mycobacillin synthesis occurs by way of linear addition of amino acid to the peptide chain.
Authors:
A B BANERJEE; S K BOSE
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  87     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1964 Jun 
Date Detail:
Created Date:  1964-12-01     Completed Date:  1996-12-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1397-401     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents*
Antifungal Agents*
Bacillus subtilis*
Chloramphenicol*
DNA, Bacterial*
Metabolism*
Peptides*
Pharmacology*
RNA, Bacterial*
Research*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/DNA, Bacterial; 0/Peptides; 0/RNA, Bacterial; 56-75-7/Chloramphenicol
Comments/Corrections

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