| Biosynthesis of lipid-linked oligosaccharides by microsomes from virus induced Hepatoma MC-29. Dependence of some glycosyl transferases on dolichyl phosphates of different chain length. | |
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MedLine Citation:
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PMID: 3158561 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dolichyl phosphates of various chain length ranging from 7 to 22 isoprene units were tested as lipid acceptors in transglycosylation reactions in chicken liver and Hepatoma MC-29. In the presence of exogenous dolichyl phosphate mixture (18 and 19 isoprene units) the synthesis of dolichyl pyrophosphate N-acetylglucosamine and dolichyl phosphate mannose increased 3 times both in the liver and Hepatoma MC-29, while the formation of dolichyl phosphate glucose was 4 fold higher in the liver and 6-fold higher in Hepatoma MC-29. In liver microsomes the maximum rate of the stimulation of glycosylation was achieved by exogenous dolichyl phosphates, containing 18 and 19 isoprene units, while glycosyl transferases in microsomes from Hepatoma MC-29 did not show any structural requirements to the chain length of dolichyl phosphates. |
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Authors:
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R T Tosheva; L I Stoykova; V I Zhivkov |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of biochemistry Volume: 17 ISSN: 0020-711X ISO Abbreviation: Int. J. Biochem. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-06-26 Completed Date: 1985-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0250365 Medline TA: Int J Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 135-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chickens Dolichol Phosphates / metabolism* Glucosyltransferases / metabolism* Hexosyltransferases / metabolism* Liver / metabolism Liver Neoplasms, Experimental / metabolism Mannosyltransferases / metabolism* Microsomes, Liver / metabolism* N-Acetylglucosaminyltransferases* Polyisoprenyl Phosphates / metabolism* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Dolichol Phosphates; 0/Polyisoprenyl Phosphates; EC 2.4.1.-/Glucosyltransferases; EC 2.4.1.-/Hexosyltransferases; EC 2.4.1.-/Mannosyltransferases; EC 2.4.1.-/N-Acetylglucosaminyltransferases; EC 2.4.1.150/N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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