Document Detail

Biosynthesis and function of melanins in hepatic pigmentary system.
MedLine Citation:
PMID:  3148917     Owner:  NLM     Status:  MEDLINE    
In this report we show the most important results obtained from our study of the pigment liver cells of Amphibia and Reptilia. Contrary to the cutaneous pigment cells that derive from the neural crest, the liver pigment cells, instead, derive from the Kupffer cells: this can be seen from the results obtained from labelled precursor incorporation experiments, not only in vivo but also in vitro, using surviving liver slices or isolated melanosomes. Chemical analysis of both liver and cutaneous melanosomes reveal a great difference in their chemical composition, and this is in agreement with the different origins of these cells. We therefore propose that: liver pigment cells of Amphibia and Reptilia should be classified as "Extra Cutaneous Pigment Cells from Histocytic Origin". As regards the function of melanins, we show that O2 is trapped by these substances. Moreover, in my laboratory we have shown in several animal species, that the superoxide dismutase activity is inversely proportional to the quantity of melanin present; thus, we think that melanin could mime SOD activity.
G Sichel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society     Volume:  1     ISSN:  0893-5785     ISO Abbreviation:  Pigment Cell Res.     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-05     Completed Date:  1989-05-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8800247     Medline TA:  Pigment Cell Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-8     Citation Subset:  IM    
Istituto di Biologia Generale, Universitá di Catania, Italy.
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MeSH Terms
Dihydroxyphenylalanine / metabolism
Liver / cytology,  metabolism*
Melanins / biosynthesis,  physiology*
Melanocytes / metabolism*,  ultrastructure
Rana esculenta
Skin / metabolism
Tyrosine / metabolism
Reg. No./Substance:
0/Melanins; 55520-40-6/Tyrosine; 63-84-3/Dihydroxyphenylalanine

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