Document Detail

Biosynthesis of flavocoenzymes.
MedLine Citation:
PMID:  16010344     Owner:  NLM     Status:  MEDLINE    
The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate. The imidazole ring of GTP is hydrolytically opened, yielding a 2,5-diaminopyrimidine that is converted to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione by a sequence of deamination, side chain reduction, and dephosphorylation. Condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3,4-dihydroxy-2-butanone 4-phosphate obtained from ribulose 5-phosphate affords 6,7-dimethyl-8-ribityllumazine. Dismutation of the lumazine derivative yields riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, which is recycled in the biosynthetic pathway. The enzymes of the riboflavin pathway are potential targets for antibacterial agents.
Markus Fischer; Adelbert Bacher
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-04-21
Journal Detail:
Title:  Natural product reports     Volume:  22     ISSN:  0265-0568     ISO Abbreviation:  Nat Prod Rep     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-12     Completed Date:  2005-07-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8502408     Medline TA:  Nat Prod Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  324-50     Citation Subset:  IM    
Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstr. 4, D-85747, Garching, Germany.
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MeSH Terms
Amino Acid Sequence
Coenzymes / biosynthesis*
Molecular Sequence Data
Molecular Structure
Multienzyme Complexes / metabolism
Protein Conformation
Riboflavin / biosynthesis*
Riboflavin Synthase / metabolism*
Reg. No./Substance:
0/Coenzymes; 0/Multienzyme Complexes; 83-88-5/Riboflavin; 89287-46-7/6,7-dimethyl-8-ribityllumazine synthase; EC Synthase

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