| Biosynthesis and excretion of gangliosides by the isolated perfused rat liver. | |
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MedLine Citation:
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PMID: 1572373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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De novo synthesis and excretion into perfusate and bile fluid of hepatic gangliosides were studied in isolated perfused rat livers. Addition of N-acetyl-[6-3H(n)]D-mannosamine to the perfusate resulted in radioactive synthesis of at least eight gangliosides labeled in their sialic acid residues. About 10% of total de novo synthesized gangliosides were excreted into the perfusate, less than 1% into the bile fluid. Labeled gangliosides were tentatively identified by cochromatography with known standards. All of them are known to occur in rat liver and sera. The results indicate that most, if not all, normal serum gangliosides are synthesized in the liver; excretion with bile fluid is negligible. They explain previous observations, and indicate clinical implications, which are discussed. |
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Authors:
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H J Senn; S Sellin; E Fitzke; T Stehle; D Häussinger; H Wieland; W Gerok |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of biochemistry / FEBS Volume: 205 ISSN: 0014-2956 ISO Abbreviation: Eur. J. Biochem. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-06-02 Completed Date: 1992-06-02 Revised Date: 2007-07-23 |
Medline Journal Info:
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Nlm Unique ID: 0107600 Medline TA: Eur J Biochem Country: GERMANY |
Other Details:
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Languages: eng Pagination: 809-14 Citation Subset: IM |
Affiliation:
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Medizinische Universitätsklinik Freiburg, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism Carbohydrate Conformation Carbohydrate Sequence Chromatography, High Pressure Liquid Chromatography, Thin Layer Female Gangliosides / biosynthesis, isolation & purification, metabolism* Lipoproteins / isolation & purification, metabolism Liver / metabolism* Molecular Sequence Data Perfusion Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Gangliosides; 0/Lipoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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