Document Detail

Biosynthesis of enzyme-bound formylvaline and formylvalylglycine. A possible initiation complex for gramicidin A biosynthesis.
MedLine Citation:
PMID:  66230     Owner:  NLM     Status:  MEDLINE    
A partially purified fraction (Component I) which catalyzed the ATP-PPi exchange reaction dependent only on valine and glycine among the five constituent amino acids of gramicidin A was obtained from crude extracts of Bacillus brevis ATCC 8185, which produces both gramicidin A and tyrocidines. This fraction was found to bind valine and glycine as thioesters. The addition of a formylTHFA synthesizing system to Component I brought about the formation of Component I-bound formylvaline and formylvalylglycine.
K Akashi; K Kubota; K Kurahashi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biochemistry     Volume:  81     ISSN:  0021-924X     ISO Abbreviation:  J. Biochem.     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-05-25     Completed Date:  1977-05-25     Revised Date:  2007-12-19    
Medline Journal Info:
Nlm Unique ID:  0376600     Medline TA:  J Biochem     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  269-72     Citation Subset:  IM    
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MeSH Terms
Bacillus / metabolism
Dipeptides / biosynthesis
Formic Acids / metabolism
Glycine / metabolism
Gramicidin / biosynthesis*
Tetrahydrofolates / biosynthesis
Valine / analogs & derivatives,  biosynthesis
Reg. No./Substance:
0/Dipeptides; 0/Formic Acids; 0/Tetrahydrofolates; 1405-97-6/Gramicidin; 56-40-6/Glycine; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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