| Biosynthesis of enediyne antitumor antibiotics. | |
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MedLine Citation:
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PMID: 18397168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The enediyne polyketides are secondary metabolites isolated from a variety of Actinomycetes. All members share very potent anticancer and antibiotic activity, and prospects for the clinical application of the enediynes has been validated with the recent marketing of two enediyne derivatives as anticancer agents. The biosynthesis of these compounds is of interest because of the numerous structural features that are unique to the enediyne family. The gene cluster for five enediynes has now been cloned and sequenced, providing the foundation to understand natures' means to biosynthesize such complex, exotic molecules. Presented here is a review of the current progress in delineating the biosynthesis of the enediynes with an emphasis on the model enediyne, C-1027. |
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Authors:
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Steven G Van Lanen; Ben Shen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current topics in medicinal chemistry Volume: 8 ISSN: 1873-4294 ISO Abbreviation: Curr Top Med Chem Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-09 Completed Date: 2008-06-05 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101119673 Medline TA: Curr Top Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 448-59 Citation Subset: IM |
Affiliation:
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Division of Pharmaceutical Sciences, University of Wisconsin, Madison, WI, 53705. bshen@pharmacy.wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actinobacteria
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chemistry,
metabolism Antibiotics, Antineoplastic / biosynthesis*, chemistry Enediynes / chemistry*, metabolism* Multigene Family Polyketide Synthases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA078747-09/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Enediynes; 79956-01-7/Polyketide Synthases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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