Document Detail


Biosynthesis of piperazic acid via N5-hydroxy-ornithine in Kutzneria spp. 744.
MedLine Citation:
PMID:  22522643     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Which came first? We have investigated the biosynthesis of the piperazic acid (Piz) building blocks in the kutzneride family of metabolites. The flavin-dependent oxygenase KtzI was shown to convert ornithine to N(5)-OH-Orn. LC-MS/MS showed (13)C(5)-labeled versions of these two amino acids to be direct precursors of piperazic acid in vivo.
Authors:
Christopher S Neumann; Wei Jiang; John R Heemstra; Erin A Gontang; Roberto Kolter; Christopher T Walsh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-20
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  13     ISSN:  1439-7633     ISO Abbreviation:  Chembiochem     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-25     Completed Date:  2012-11-01     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  972-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Actinomycetales / chemistry,  metabolism*
Amino Acids / chemistry
Ornithine / analogs & derivatives*,  chemistry,  metabolism
Pyridazines / chemistry,  metabolism*
Tandem Mass Spectrometry / methods
Grant Support
ID/Acronym/Agency:
F32 GM087941/GM/NIGMS NIH HHS; F32M083464//PHS HHS; F32M087941//PHS HHS; GM020011/GM/NIGMS NIH HHS; GM082137/GM/NIGMS NIH HHS; R01 GM082137/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Pyridazines; 32750-52-0/piperazic acid; 35187-58-7/delta-N-hydroxyornithine; 7006-33-9/Ornithine
Comments/Corrections

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