Document Detail


Biosynthesis of N-acetylglucosamine-P-P-dolichol, the committed step of asparagine-linked oligosaccharide assembly.
MedLine Citation:
PMID:  1668306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asparagine-linked glycosylation is initiated by the synthesis of N-acetylglucosaminylpyrophosphoryl dolichol (GlcNAc-P-P-dolichol), which is extended by a series of glycosyltransferases to yield Glc3Man9GlcNAc2-P-P-dolichol (where Glc is glucose and Man is mannose). The oligosaccharide unit is then transferred en bloc to asparagine residues of nascent polypeptides in the lumen of the rough endoplasmic reticulum. The question here is whether GlcNAc-P-P-dolichol biosynthesis is a fixed process unaffected by cellular events, or a regulated reaction responsive to cellular requirements for glycoprotein biosynthesis. Several lines of evidence indicate that the latter is the case and that GlcNAc-P-P-dolichol biosynthesis may be subject to multiple forms of regulation. Recent information about the N-acetylglucosamine-1-P transferase (GPT) responsible for this reaction and the cloning of cDNA candidates for this enzyme have provided further insight into these mechanisms. This review will examine current hypotheses dealing with GPT and its role in the committed step of asparagine-linked glycosylation.
Authors:
M A Lehrman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Glycobiology     Volume:  1     ISSN:  0959-6658     ISO Abbreviation:  Glycobiology     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-09-01     Completed Date:  1992-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9104124     Medline TA:  Glycobiology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  553-62     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Asparagine*
Glycosylation
Glycosyltransferases / metabolism*
Molecular Sequence Data
Oligosaccharides / biosynthesis*
Phosphotransferases / genetics,  metabolism*
Polyisoprenyl Phosphate Monosaccharides / metabolism*
Saccharomyces cerevisiae / enzymology
Sequence Homology, Nucleic Acid
Transferases (Other Substituted Phosphate Groups)*
Chemical
Reg. No./Substance:
0/Oligosaccharides; 0/Polyisoprenyl Phosphate Monosaccharides; 56938-89-7/N-acetylglucosaminylpyrophosphoryldolichol; 7006-34-0/Asparagine; EC 2.4.-/Glycosyltransferases; EC 2.7.-/Phosphotransferases; EC 2.7.8.-/Transferases (Other Substituted Phosphate Groups); EC 2.7.8.15/UDPacetylglucosamine-dolichyl-phosphate acetylglucosamine-1-phosphate transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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