| Biosynthesis and Cellular Localization of Functional Polyketides in the Gastropod Mollusc Scaphander lignarius. | |
| | |
MedLine Citation:
|
PMID: 22829532 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Opisthobranchs belong to a subclass of highly evolved and specialised marine gastropods that rely on the use of secondary metabolites for their survival. Here we report the full elucidation of the biosynthesis of aromatic metabolites, lignarenones, in one of these gastropods, the cephalaspidean Scaphander lignarius. Feeding experiments with (2) H- and (13) C-labelled precursors revealed a mixed acetate/propionate polyketide pathway primed by benzoic acid. Phenylalanine ammonia lyase (PAL), unprecedented in animals, is central to the synthesis of this aromatic precursor by oxidative deamination of L-phenylalanine to cinnamic acid. Lignarenones are synthesised in the cytoplasm of specialised eukaryotic cells named Blochmann's glands, which are distributed in biosynthetic tissue localised in the vulnerable mantle of the mollusc. This result supports the hypothesis that this lineage of gastropods has acquired the genetic information to produce the chemical substances that they use for their survival. |
| | |
Authors:
|
Adele Cutignano; Conxita Avila; Annamaria Rosica; Giovanna Romano; Bruna Laratta; Anna Domenech-Coll; Guido Cimino; Ernesto Mollo; Angelo Fontana |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-24 |
Journal Detail:
|
Title: Chembiochem : a European journal of chemical biology Volume: - ISSN: 1439-7633 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100937360 Medline TA: Chembiochem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Consiglio Nazionale delle Ricerch, Istituto di Chimica Biomolecolare, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli (Italy). |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Light-Controlled Tools.
Next Document: Biodegradable balloon-expandable self-locking polycaprolactone stents as buckling explants for the t...