Document Detail

Biosensor plates detect mitochondrial physiological regulators and mutations in vivo.
MedLine Citation:
PMID:  18950600     Owner:  NLM     Status:  MEDLINE    
The measurement of mitochondrial activity in living cells is usually not straightforward, even though it is quite important in physiological and pathophysiological processes. We describe a high-throughput method for measurement of mitochondrial oxygen consumption in living cells, based on the Becton-Dickinson Biosensor plates.
Anabela P Rolo; Carlos M Palmeira; Gino A Cortopassi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-10-07
Journal Detail:
Title:  Analytical biochemistry     Volume:  385     ISSN:  1096-0309     ISO Abbreviation:  Anal. Biochem.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2008-12-29     Completed Date:  2009-03-03     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0370535     Medline TA:  Anal Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  176-8     Citation Subset:  IM    
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MeSH Terms
Biosensing Techniques / methods*
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone / pharmacology
Dose-Response Relationship, Drug
Mitochondrial Proteins / analysis*,  genetics*,  metabolism
Oxygen Consumption
Point Mutation / genetics*
Time Factors
Tumor Cells, Cultured
Grant Support
AG11967/AG/NIA NIH HHS; AG16719/AG/NIA NIH HHS; AG23311/AG/NIA NIH HHS; EY12245/EY/NEI NIH HHS; P01 AG025532/AG/NIA NIH HHS; P01 AG025532-01A1/AG/NIA NIH HHS; P01 AG025532-01A10003/AG/NIA NIH HHS; R01 AG011967/AG/NIA NIH HHS; R01 AG011967-13/AG/NIA NIH HHS; R01 AG016719/AG/NIA NIH HHS; R01 AG016719-10/AG/NIA NIH HHS; R01 EY012245/EY/NEI NIH HHS; R01 EY012245-09/EY/NEI NIH HHS; R01 NS077777/NS/NINDS NIH HHS
Reg. No./Substance:
0/Mitochondrial Proteins; 370-86-5/Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone

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