| Biosafety of flavonoids in rats: effects on copper and zinc homeostasis and interaction with low-level pesticide exposure. | |
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MedLine Citation:
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PMID: 19099207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two 30-day experiments (36 male Sprague-Dawley rats each) were conducted to determine effect of administering flavonoid mixture (FM) with concomitant exposure to a pesticide mixture (PM) or FM at varied levels on changes in concentrations of zinc and copper in tissues. In experiment 1, PM = chlorpyrifos, endosulfan, and thiram at 25% LD(50) was dissolved in soybean (SB) oil and gavage-fed 0.1 mL 5 days/week; FM in SB oil was mixed in AIN-93M diet at 1.0 and 5.0 mM/kg diet and fed ad libitum. The groups were Control (CON), PM, FM1, FM5, PM+FM1, and PM+FM5. In experiment 2, FM in 1% polyethylene glycol was gavage-fed (0.5 mL/5 days/week), at increasing levels(mg/kg body weight); the groups were CON, FM5, FM25, FM50, FM100, and FM200. In experiment 1, PM plus FM increased tissue Cu as compared to the CON by: plasma, 16-37%; liver, 9-20%; kidney, 13-41%; small intestinal mucosa (IM), 41%; and small intestines (SI), 77%. In experiment 2, FM fed at higher levels decreased tissue Cu by: plasma, 22-36%; liver, 23%; kidney, 24-44%; IM, 17-26%; and SI, 58% and 77%, as compared to respective CON. Kidney zinc increased at higher concentrations of FM by 14-34%. These results indicate that flavonoids can modify copper homeostasis depending on whether they are fed in the diet or by gavage. |
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Authors:
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Frederick N Bebe; Myna Panemangalore |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-12-20 |
Journal Detail:
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Title: Biological trace element research Volume: 129 ISSN: 1559-0720 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-22 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
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Languages: eng Pagination: 200-12 Citation Subset: IM |
Affiliation:
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Nutrition and Health Program, Kentucky State University, Frankfort, KY 40601, USA. frederick.bebe@kysu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animals Copper / blood, metabolism* Flavonoids / administration & dosage, pharmacology* Homeostasis / drug effects* Male Pesticides / pharmacology* Rats Rats, Sprague-Dawley Zinc / blood, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Flavonoids; 0/Pesticides; 7440-50-8/Copper; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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