Document Detail

Biosafety and Bioapplication of Nanomaterials by Designing Protein-Nanoparticle Interactions.
MedLine Citation:
PMID:  23341247     Owner:  NLM     Status:  Publisher    
The protein-nanoparticle (NP) interface is a current frontier of multiple disciplines, full of challenges and opportunities. The unique behaviors of nanomaterials (NMs) bring many exciting applications, and also raise safety concerns. Beyond bioapplications, various NMs could also enter human bodies from the environment. When entering human bodies, NPs interact with various biomolecules, especially proteins, forming a protein corona. This protein-NP complex is what the biosystems 'see' and 'respond to'. Therefore, understanding how NPs interact with proteins is crucial for both bioapplications and the biosafety of NMs. In this review, the current understanding of protein-NP interactions is summarized, including the theoretical background, experimental results, and computational progresses. Guidelines for improving bioapplication performance and reducing the potential biosafety hazard of NMs by designing the protein-NP interactions are discussed, along with future directions and challenges in this exciting field.
Sheng-Tao Yang; Ying Liu; Yan-Wen Wang; Aoneng Cao
Related Documents :
8449447 - Two-dimensional electrophoretic analysis of endometrial cellular proteins synthesized d...
23612307 - The four-transmembrane protein ip39 of euglena forms strands by a trimeric unit repeat.
23665327 - Ubiquitination of the heterotrimeric g protein α subunits gαi2 and gαq is prevented ...
24870237 - Accurate design of co-assembling multi-component protein nanomaterials.
20529957 - Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.
2138677 - Preferred apical distribution of glycosyl-phosphatidylinositol (gpi) anchored proteins:...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Small (Weinheim an der Bergstrasse, Germany)     Volume:  -     ISSN:  1613-6829     ISO Abbreviation:  Small     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235338     Medline TA:  Small     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, China; College of Chemistry and Environment, Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Femoral neck structure and function in early hominins.
Next Document:  Silver nanoparticle toxicity effect on growth and cellular viability of the aquatic plant Lemna gibb...