Document Detail

Bioreactors for development of tissue engineered heart valves.
MedLine Citation:
PMID:  20820920     Owner:  NLM     Status:  MEDLINE    
Millions of people worldwide are diagnosed each year with valvular heart disease, resulting in hundreds of thousands of valve replacement operations. Prosthetic valve replacements are designed to correct narrowing or backflow through the valvular orifice. Although commonly used, these therapies have serious disadvantages including morbidity associated with long-term anticoagulation and limited durability necessitating repeat operations. The ideal substitute would be widely available and technically implantable for most cardiac surgeons, have normal hemodynamic performance, low risk for structural degeneration, thrombo-embolism and endocarditis, and growth potential for pediatric patients. Tissue engineered heart valves hold promise as a viable substitute to outperform existing valve replacements. An essential component to the development of tissue engineered heart valves is a bioreactor. It is inside the bioreactor that the scaffold and cells are gradually conditioned to the biochemical and mechanical environment of the valve to be replaced.
Joel L Berry; Julie A Steen; J Koudy Williams; James E Jordan; Anthony Atala; James J Yoo
Publication Detail:
Type:  Journal Article; Review     Date:  2010-09-04
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-01-21     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3272-9     Citation Subset:  IM    
Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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MeSH Terms
Heart Valve Prosthesis*
Heart Valves*
Tissue Engineering / methods*

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