Document Detail


Bioreactor and scaffold design for the mechanical stimulation of anterior cruciate ligament grafts.
MedLine Citation:
PMID:  23629535     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Various studies have shown that physical stimuli modulate cell function and this has motivated the development of a bioreactor to engineer tissues in vitro by exposing them to mechanical loads. Here, we present a bioreactor for the physical stimulation of anterior cruciate ligament (ACL) grafts, whereby complex multi-dimensional strain can be applied to the matrices. Influences from environmental conditions to the behavior of different cells on our custom-made silk scaffold can be investigated since the design of the bioreactor allows controlling these parameters precisely. With the braided design of the presented silk scaffold we achieve maximum loads and stiffness values matching those of the human ACL. Thus, the existent degummed and wet silk scaffolds absorb maximum loads of 2030±109 N with stiffness values of 336±40 N/mm.
Authors:
M Hohlrieder; A H Teuschl; K Cicha; M van Griensven; H Redl; J Stampfl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bio-medical materials and engineering     Volume:  23     ISSN:  1878-3619     ISO Abbreviation:  Biomed Mater Eng     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-04-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104021     Medline TA:  Biomed Mater Eng     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  225-37     Citation Subset:  IM    
Affiliation:
A.M.I. Agency for Medical Innovations, Feldkirch, Austria.
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