Document Detail

Bioprosthetic valve degeneration due to cholesterol deposition in a patient with normal lipid profile.
MedLine Citation:
PMID:  17347697     Owner:  NLM     Status:  MEDLINE    
Hypercholesterolemia has been identified as a risk factor for bioprosthetic valvular degeneration, and it has been suggested that statin therapy reduces this risk. The case of a 77-year-old man with low levels of low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B who developed marked LDL-C crystal deposition and a severe foreign body giant cell reaction 21.5 years after aortic bioprosthetic replacement is reported. This observation confirms that cholesterol deposition contributes to bioprosthetic valve degeneration, but that this can occur even in patients with low levels of LDL-C. It suggests that the characteristics of the valve are more critical than the patient's level of LDL-C.
Leslie Price; Allan Sniderman; Attila Omerglu; Kevin Lachapelle
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  23     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-09     Completed Date:  2007-04-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  233-4     Citation Subset:  IM    
McGill University Health Centre, Montreal, Quebec.
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MeSH Terms
Aortic Valve Stenosis / surgery*
Apolipoproteins B / blood
Cholesterol, LDL / blood
Heart Valve Prosthesis*
Heart Valve Prosthesis Implantation / instrumentation
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hypercholesterolemia / blood*,  drug therapy
Prosthesis Failure
Reg. No./Substance:
0/Apolipoproteins B; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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