Document Detail

Bioprosthetic heart valves: modes of failure.
MedLine Citation:
PMID:  19694820     Owner:  NLM     Status:  MEDLINE    
Valve replacement started in 1960, with the surgeon now having a significant variety of prosthetic heart valves from which to choose. These valves are broadly divided into mechanical heart valves (MHV) and bioprosthetic heart valves (BHV). Improvements in the performance and ease of usage of BHV without the need for anticoagulant therapy are among the desired features of BHV and hence the increasingly preferred choice over their mechanical counterparts. However, with increased use the post-implantation complications have become more apparent, and these include: calcification, cusp tears, pannus growth, infective endocarditis, valve thrombosis and other factors specific to valve type. In this review we describe these complications in order to bring awareness among surgeons, clinicians and pathologists. Diagnosis, treatment and preventive measures, if taken in a timely manner, can help reduce their impact and further enhance the quality of life of patients with prosthetic heart valves.
Raheela Fareed Siddiqui; Johnathan Rajiv Abraham; Jagdish Butany
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Histopathology     Volume:  55     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  135-44     Citation Subset:  IM    
Department of Pathology, Toronto General Hospital/University Health Network, Toronto, ON M5G 2C4, Canada.
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MeSH Terms
Calcinosis / etiology
Endocarditis / etiology
Heart Valve Prosthesis / adverse effects*
Heart Valve Prosthesis Implantation / adverse effects*
Heart Valves / surgery
Postoperative Complications / surgery
Prosthesis Design / adverse effects*
Prosthesis Failure*
Thrombosis / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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