Document Detail

Bioprobes for investigating mammalian cell cycle control.
MedLine Citation:
PMID:  9918389     Owner:  NLM     Status:  MEDLINE    
Bioprobes are low molecular weight compounds which are useful for investigating mammalian cell functions. The use of bioprobes has substantially assisted the investigation of complex biochemical processes of the mammalian cell cycle. In this review, cell cycle inhibitors mainly isolated from the microorganism are described and their possibility as an antitumor agents is considered. Most cancer cells have some abnormality in the control mechanism of cell cycle progression. Cyclin-dependent kinases (Cdk), which are activated by the binding with the cyclin and simultaneously by the phosphorylation/dephosphorylation of itself, play important roles as engines in the cell cycle. Tubulins are considered to be one of the most important proteins of the cell division machinery. Therefore, Cdk inhibitors and tubulin binders are possible anticancer drugs. Since the function of proteins controlling the cell cycle is also regulated by phosphorylation and dephosphorylation, inhibitors of protein kinases and phosphatases are considered as possible an antitumor agents. We expect that some bioprobes will be developed for clinical use.
H Osada
Related Documents :
9652739 - Retinoblastoma protein-overexpressing hl60 cells resistant to 1,25-dihydroxyvitamin d3 ...
9466669 - Overexpression of p21waf1/cip1 induces cell differentiation and growth inhibition in a ...
20714219 - Cyclin t1 overexpression induces malignant transformation and tumor growth.
8980229 - Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during drosophila...
18981479 - Differentiation of trophoblast stem cells into giant cells is triggered by p57/kip2 inh...
15796209 - Cell cycle and apoptosis deregulation in classical hodgkin lymphomas.
19251319 - Interleukin-6 stimulates cell migration, invasion and integrin expression in htr-8/svne...
22358579 - Establishment of cell lines from serial samples from two patients with lung tumours bef...
8530379 - Synthesis and intracellular transport of aminoglycerophospholipids in permeabilized cel...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  51     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-09     Completed Date:  1999-02-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  973-82     Citation Subset:  IM    
The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents / pharmacology
Biosensing Techniques*
Cell Cycle / drug effects*
Cyclin-Dependent Kinases / antagonists & inhibitors*,  metabolism
Protein Kinase Inhibitors*
Tubulin / metabolism
Reg. No./Substance:
0/Antineoplastic Agents; 0/Protein Kinase Inhibitors; 0/Tubulin; EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Electrocardiographic changes during insulin-induced hypoglycemia in healthy subjects.
Next Document:  Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ra...