Document Detail

Biopreservation of red blood cells: past, present, and future.
MedLine Citation:
PMID:  15852241     Owner:  NLM     Status:  MEDLINE    
Preservation and long-term storage of red blood cells (RBCs) is needed to ensure a readily available, safe blood supply for transfusion medicine. Effective preservation procedures are required at various steps in the production of a RBC product including testing, inventory, quality control, and product distribution. Biopreservation is the process of maintaining the integrity and functionality of cells held outside the native environment for extended storage times. The biopreservation of RBCs for clinical use can be categorized based on the techniques used to achieve biologic stability and ensure a viable state after long-term storage. This paper will review the history, science, current practices, and emerging technologies of current RBC biopreservation approaches: hypothermic storage, cryopreservation, and lyophilization.
Kirby L Scott; Jelena Lecak; Jason P Acker
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Transfusion medicine reviews     Volume:  19     ISSN:  0887-7963     ISO Abbreviation:  Transfus Med Rev     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-26     Completed Date:  2005-08-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8709027     Medline TA:  Transfus Med Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-42     Citation Subset:  IM    
Canadian Blood Services, Research and Development, and Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton.
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MeSH Terms
Blood Component Transfusion / methods
Blood Preservation / methods*,  trends
Cold Temperature
Cryopreservation / methods*
Cryoprotective Agents / administration & dosage*,  metabolism
Erythrocyte Transfusion / methods*
Erythrocytes / cytology*,  drug effects*,  physiology
Freeze Drying
Glycerol / chemistry
Models, Biological
Preservation, Biological / methods*,  trends
Specimen Handling
Reg. No./Substance:
0/Cryoprotective Agents; 56-81-5/Glycerol

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