| Biophysics and function of phosphatidic acid: a molecular perspective. | |
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MedLine Citation:
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PMID: 19362164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phosphatidic acid is the simplest (diacyl)glycerophospholipid present in cells and is now a well established second messenger with direct biological functions. It is specifically recognized by diverse proteins and plays an important role in cellular signaling and membrane dynamics in all eukaryotes. An important determinant of the biological functions of phosphatidic acid is its anionic headgroup. In this review we will focus on the peculiar ionization properties of phosphatidic acid and their crucial role in lipid-protein interactions. We will take a molecular approach focusing entirely on the physical chemistry of the lipid and develop a model explaining the ionization properties of phosphatidic acid, termed the electrostatic-hydrogen bond switch model. Diverse examples from recent literature in support of this model will be presented and the broader implications of our findings will be discussed. |
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Authors:
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Edgar Eduard Kooijman; Koert N J Burger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-04-09 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1791 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-25 Completed Date: 2009-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 881-8 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Kent State University, Kent, OH, USA. ekooijma@kent.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biophysical Phenomena* Hydrogen Bonding Lipid Bilayers / metabolism Models, Biological Phosphatidic Acids / chemistry*, metabolism* Static Electricity |
| Chemical | |
Reg. No./Substance:
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0/Lipid Bilayers; 0/Phosphatidic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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