Document Detail

Biophysics and function of phosphatidic acid: a molecular perspective.
MedLine Citation:
PMID:  19362164     Owner:  NLM     Status:  MEDLINE    
Phosphatidic acid is the simplest (diacyl)glycerophospholipid present in cells and is now a well established second messenger with direct biological functions. It is specifically recognized by diverse proteins and plays an important role in cellular signaling and membrane dynamics in all eukaryotes. An important determinant of the biological functions of phosphatidic acid is its anionic headgroup. In this review we will focus on the peculiar ionization properties of phosphatidic acid and their crucial role in lipid-protein interactions. We will take a molecular approach focusing entirely on the physical chemistry of the lipid and develop a model explaining the ionization properties of phosphatidic acid, termed the electrostatic-hydrogen bond switch model. Diverse examples from recent literature in support of this model will be presented and the broader implications of our findings will be discussed.
Edgar Eduard Kooijman; Koert N J Burger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-04-09
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1791     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  881-8     Citation Subset:  IM    
Department of Biological Sciences, Kent State University, Kent, OH, USA.
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MeSH Terms
Biophysical Phenomena*
Hydrogen Bonding
Lipid Bilayers / metabolism
Models, Biological
Phosphatidic Acids / chemistry*,  metabolism*
Static Electricity
Reg. No./Substance:
0/Lipid Bilayers; 0/Phosphatidic Acids

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