| Biophysical studies of the nucleic acid chaperone properties of the HIV-1 nucleocapsid protein. | |
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MedLine Citation:
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PMID: 21045545 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The nucleocapsid protein NCp7 of HIV-1 possesses nucleic acid chaperone properties that are thought to be crucial throughout the viral life cycle. These properties promote the rearrangement of nucleic acids into their most thermodynamically stable conformations. These NCp7 properties involve two components, namely nucleic acid destabilization and activation of the annealing of complementary sequences. Biophysical techniques have been found extremely powerful to decipher the molecular mechanisms underlying these two components. We propose here an overview of the recent reports that examine the nucleic acid chaperone properties of NCp7 by these techniques. |
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Authors:
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Julien Godet; Yves Mély |
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Publication Detail:
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Type: Journal Article Date: 2010-11-01 |
Journal Detail:
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Title: RNA biology Volume: 7 ISSN: 1555-8584 ISO Abbreviation: RNA Biol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235328 Medline TA: RNA Biol Country: United States |
Other Details:
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Languages: eng Pagination: 687-99 Citation Subset: IM |
Affiliation:
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Laboratoire de Biophotonique et Pharmacologie, UMR 7213 CNRS, Université de Strasbourg, Faculté de Pharmacie; Illkirch, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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