Document Detail

Biophysical studies of ion channels.
MedLine Citation:
PMID:  6089347     Owner:  NLM     Status:  MEDLINE    
Ionic channels, the integral membrane proteins responsible for the brain's electrical activity, have long been studied with standard electrophysiological and biochemical methods. Recently, however, newly developed electrical and molecular biological methods have been brought to bear on long-standing questions in neurobiology. Goals of current channel research include elucidating the primary amino acid sequence and three-dimensional structure of channel species; the mechanisms of synthesis, sorting, membrane insertion, and degradation; and aspects of function such as gating, ion permeation and selectivity, and regulation. The latest research combines the new biochemical and electrophysiological techniques to reveal relations between molecular structure and function.
C F Stevens
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  225     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-10-10     Completed Date:  1984-10-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1346-50     Citation Subset:  IM    
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MeSH Terms
DNA / analysis
Ion Channels / physiology*
Macromolecular Substances
Membrane Proteins / physiology
Models, Neurological
Molecular Weight
Nervous System Physiological Phenomena*
Receptors, Cholinergic / genetics,  physiology*
Reg. No./Substance:
0/Ion Channels; 0/Macromolecular Substances; 0/Membrane Proteins; 0/Receptors, Cholinergic; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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