| Biophysical probes of iron metabolism in cells and organelles. | |
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MedLine Citation:
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PMID: 21282072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In living systems, iron is found in many different structures, including Fe/S clusters, hemes and nonheme centers, and magnetically interacting aggregates. Understanding Fe metabolism and trafficking will require biophysical spectroscopic tools that can evaluate the types of Fe centers within entire cells and isolated organelles. Mössbauer spectroscopy will play an important role in such analyses, as it has perhaps the best combination of resolution, sensitivity, coverage, and quantifying abilities. Other spectroscopic techniques, with particular strengths, will be used in combination with Mössbauer, and results will be integrated to assess the 'ironome' of such complex samples. This integrative biophysical approach is illustrated by a discussion of iron trafficking in yeast cells. |
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Authors:
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Paul A Lindahl; Gregory P Holmes-Hampton |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-02-01 |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 15 ISSN: 1879-0402 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-11 Completed Date: 2011-08-04 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 342-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA. Lindahl@chem.tamu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fungal Proteins / chemistry, metabolism Fungi / chemistry, metabolism Humans Iron / analysis*, chemistry, metabolism* Iron-Binding Proteins / chemistry*, metabolism Spectroscopy, Mossbauer / methods* |
| Grant Support | |
ID/Acronym/Agency:
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GM084266/GM/NIGMS NIH HHS; R01 GM084266-03/GM/NIGMS NIH HHS; T32 GM008523-14/GM/NIGMS NIH HHS; T32GM008523/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; 0/Iron-Binding Proteins; 7439-89-6/Iron |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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