Document Detail

Biophysical model of synaptic plasticity dynamics.
MedLine Citation:
PMID:  14504940     Owner:  NLM     Status:  MEDLINE    
We discuss a biophysical model of synaptic plasticity that provides a unified view of the outcomes of synaptic modification protocols, including: (1) prescribed time courses of postsynaptic intracellular Ca(2+) release, (2) postsynaptic voltage clamping with presentation of presynaptic spike trains at various frequencies, (3) direct postsynaptic response to presynaptic spike trains at various frequencies, and (4) LTP/LTD as a response to precisely timed presynaptic and postsynaptic spikes.
Henry D I Abarbanel; Leif Gibb; R Huerta; M I Rabinovich
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2003-07-31
Journal Detail:
Title:  Biological cybernetics     Volume:  89     ISSN:  0340-1200     ISO Abbreviation:  Biol Cybern     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-23     Completed Date:  2003-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7502533     Medline TA:  Biol Cybern     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  214-26     Citation Subset:  IM    
Institute for Nonlinear Science, Center for Theoretical Biological Physics, Marine Physical Laboratory (Scripps Institution of Oceanography) and Department of Physics, University of California, San Diego, La Jolla, CA 93093-0402, USA.
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MeSH Terms
Calcium / metabolism
Calcium Channels / physiology
Dose-Response Relationship, Drug
Electric Stimulation
Excitatory Postsynaptic Potentials
Hippocampus / drug effects,  physiology
Magnesium / pharmacology
Models, Biological*
Neuronal Plasticity / physiology*
Neurons / drug effects,  physiology
Nonlinear Dynamics*
Presynaptic Terminals / physiology
Reaction Time / physiology
Receptors, AMPA / physiology
Receptors, N-Methyl-D-Aspartate / physiology
Synapses / drug effects,  physiology*
Synaptic Transmission
Time Factors
Reg. No./Substance:
0/Calcium Channels; 0/Receptors, AMPA; 0/Receptors, N-Methyl-D-Aspartate; 7439-95-4/Magnesium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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