| Biophysical model of the spatial heterogeneity of myocardial flow. | |
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MedLine Citation:
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PMID: 19450475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The blood flow in the myocardium has significant spatial heterogeneity. The objective of this study was to develop a biophysical model based on detailed anatomical data to determine the heterogeneity of regional myocardial flow during diastole. The model predictions were compared with experimental measurements in a diastolic porcine heart in the absence of vessel tone using nonradioactive fluorescent microsphere measurements. The results from the model and experimental measurements showed good agreement. The relative flow dispersion in the arrested, vasodilated heart was found to be 44% and 48% numerically and experimentally, respectively. Furthermore, the flow dispersion was found to have fractal characteristics with fractal dimensions (D) of 1.25 and 1.27 predicted by the model and validated by the experiments, respectively. This validated three-dimensional model of normal diastolic heart will play an important role in elucidating the spatial heterogeneity of coronary blood flow, and serve as a foundation for understanding the interplay between cardiac mechanics and coronary hemodynamics. |
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Authors:
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Yunlong Huo; Benjamin Kaimovitz; Yoram Lanir; Thomas Wischgoll; Julien I E Hoffman; Ghassan S Kassab |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biophysical journal Volume: 96 ISSN: 1542-0086 ISO Abbreviation: Biophys. J. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-19 Completed Date: 2009-08-05 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0370626 Medline TA: Biophys J Country: United States |
Other Details:
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Languages: eng Pagination: 4035-43 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Surgery, and Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biophysical Processes* Coronary Circulation* Diastole / physiology Heart / physiology Models, Anatomic Models, Biological* Reproducibility of Results Swine |
| Grant Support | |
ID/Acronym/Agency:
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HL084529/HL/NHLBI NIH HHS; HL087235/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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