| Biophysical assessment of atopic dermatitis skin and effects of a moisturizer. | |
| | |
MedLine Citation:
|
PMID: 16487108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The mechanisms of the skin barrier impairment in patients with atopic dermatitis (AD) are still unknown and need further studying. OBJECTIVE: We evaluated the skin of healthy subjects and of patients having atopic dermatitis with an instrument measuring electrical impedance and other noninvasive methods (transepidermal water loss, capacitance) and studied the effects of a new emollient [Proderm (Pro-Q in the USA)]. METHODS: After a 2-week washout period, we treated clinically noneczematous skin on the forearm of 24 patients with AD and assessed the effects with the noninvasive methods. 22 healthy subjects were used as controls. RESULTS: The findings indicate that barrier function and hydration, and certain patterns of electrical impedance of AD skin are abnormal compared with normal skin. Moreover, there was an increase in hydration in patients' skin after treatment and a reversal of certain impedance indices towards normal. CONCLUSIONS: Our findings demonstrate that the moisturizer we used changes some biophysical parameters when applied to atopic skin. In addition, a technique based on electrical impedance seems to give valuable information in atopic skin studies, especially the effects of moisturizers. |
| | |
Authors:
|
L Hagströmer; N Kuzmina; J Lapins; T Talme; L Emtestam |
Related Documents
:
|
8270338 - Epidermodysplasia verruciformis in africans. 17250538 - In vivo study of skin mechanical properties in raynaud's phenomenon. 6416538 - Development of cutaneous gangrene during continuous peripheral infusion of vasopressin. 19999878 - Cutaneous sensory loss following primary total knee arthroplasty. a two years follow-up... 16429088 - A risk-taking "set" in a novel task among adolescents with serious conduct and substanc... 19590228 - Impact of anemia on aortic pulse wave velocity in hemodialysis patients. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical and experimental dermatology Volume: 31 ISSN: 0307-6938 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-02-20 Completed Date: 2006-08-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: England |
Other Details:
|
Languages: eng Pagination: 272-7 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Section of Dermatology and Venereology, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden. lena.hagstromer@karolinska.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Case-Control Studies Dermatitis, Atopic / physiopathology* Electric Impedance Emollients* Humans Male Middle Aged Water Loss, Insensible / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Emollients |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transfection and ligation of CD40 in human oral keratinocytes affect proliferation, adhesion and mig...
Next Document: Analysis of GM-CSF gene polymorphisms (3606T/C and 3928C/T) in Japanese patients with atopic dermati...