| A biophysical model of electrical activity in human β-cells. | |
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MedLine Citation:
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PMID: 21081067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their electrophysiological characteristics, from rodent β-cells. Hence, from a clinical perspective and to obtain insight into the defects in insulin secretion relevant for diabetes mellitus, it is important to study human β-cells. This work presents the first mathematical model of electrical activity based entirely on published ion channel characteristics of human β-cells. The model reproduces satisfactorily a series of experimentally observed patterns in human β-cells, such as spiking and rapid bursting electrical activity, and their response to a range of ion channel antagonists. The possibility of Human Ether-a-Go-Go-related- and leak channels as drug targets for diabetes treatment is discussed based on model results. |
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Authors:
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Morten Gram Pedersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biophysical journal Volume: 99 ISSN: 1542-0086 ISO Abbreviation: Biophys. J. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2011-03-02 Revised Date: 2011-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370626 Medline TA: Biophys J Country: United States |
Other Details:
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Languages: eng Pagination: 3200-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Information Engineering, University of Padua, Padua, Italy. pedersen@dei.unipd.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biophysical Phenomena*
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drug effects Calcium Channels, L-Type / metabolism Computer Simulation Electricity* Electrophysiological Phenomena* / drug effects Humans Insulin-Secreting Cells / drug effects, physiology* Ion Channel Gating / drug effects Membrane Potentials / drug effects Membrane Transport Modulators / pharmacology Models, Biological* Potassium Channels / metabolism Sodium Channels / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels, L-Type; 0/Membrane Transport Modulators; 0/Potassium Channels; 0/Sodium Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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