Document Detail


Biophysical Analysis of Dystrophic and Osteogenic Models of Valvular Calcification.
MedLine Citation:
PMID:  25405546     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Calcific aortic valve disease is a significant cardiovascular disorder characterized by the formation of calcific nodules on the valve. In vitro assays studying the formation of these nodules were developed and have led to many significant mechanistic findings; however, the biophysical properties of calcific nodules have not been clearly defined. A thorough analysis of dystrophic and osteogenic nodules utilizing SEM-EDS and AFM was conducted to describe calcific nodule properties and provide a link between calcific nodule morphogenesis in vitro and in vivo. Unique nodule properties were observed for dystrophic and osteogenic nodules highlighting the distinct mechanisms occurring in valvular calcification.
Authors:
Joseph Chen; Jon Peacock; Janelle L Branch; W David Merryman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-1
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  -     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-18     Completed Date:  -     Revised Date:  2014-11-19    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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