Document Detail

Biopharming to increase bioactive peptides in rice seed.
MedLine Citation:
PMID:  18727558     Owner:  NLM     Status:  MEDLINE    
The production of high-value pharmaceutical proteins and peptides in transgenic plants is an attractive and economically feasible alternative to conventional mammalian cell, yeast, and bacterial systems. In contrast to vegetative tissues, rice seeds allow higher accumulation of recombinant proteins and long-term stable storage. Rice is not only consumed as a staple food by a majority of the world's population, but is also used as a model monocot for biotechnological manipulation. Daily oral consumption of transgenic rice seeds that accumulate high concentrations of food-derived or synthetic bioactive peptides can be expected to provide a safe, reliable, and consistent oral delivery system that would contribute to the promotion of human health care.
Lijun Yang; Yuhya Wakasa; Fumio Takaiwa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of AOAC International     Volume:  91     ISSN:  1060-3271     ISO Abbreviation:  J AOAC Int     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9215446     Medline TA:  J AOAC Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  957-64     Citation Subset:  IM    
Transgenic Crop Research and Development Center, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba Ibaraki 305-8602, Japan.
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MeSH Terms
Oryza sativa / chemistry*,  growth & development
Peptides / chemistry,  pharmacology
Plant Proteins / biosynthesis,  chemistry*,  pharmacology
Plants, Genetically Modified / chemistry*,  growth & development
Seeds / chemistry
Reg. No./Substance:
0/Peptides; 0/Plant Proteins

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