| Biopharmaceuticals derived from genetically modified plants. | |
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MedLine Citation:
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PMID: 15496527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Modern biotechnology has resulted in a resurgence of interest in the production of new therapeutic agents using botanical sources. With nearly 500 biotechnology products approved or in development globally, and with production capacity limited, the need for efficient means of therapeutic protein production is apparent. Through genetic engineering, plants can now be used to produce pharmacologically active proteins, including mammalian antibodies, blood product substitutes, vaccines, hormones, cytokines, and a variety of other therapeutic agents. Efficient biopharmaceutical production in plants involves the proper selection of host plant and gene expression system, including a decision as to whether a food crop or a non-food crop is more appropriate. Product safety issues relevant to patients, pharmaceutical workers, and the general public must be addressed, and proper regulation and regulatory oversight must be in place prior to commercial plant-based biopharmaceutical production. Plant production of pharmaceuticals holds great potential, and may become an important production system for a variety of new biopharmaceutical products. |
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Authors:
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D A Goldstein; J A Thomas |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: QJM : monthly journal of the Association of Physicians Volume: 97 ISSN: 1460-2725 ISO Abbreviation: QJM Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-21 Completed Date: 2005-03-24 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9438285 Medline TA: QJM Country: England |
Other Details:
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Languages: eng Pagination: 705-16 Citation Subset: IM |
Affiliation:
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Monsanto Company A2NE, 800 N. Lindbergh Blvd, St Louis, MO 63167, USA. daniel.a.goldstein@monsanto.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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metabolism Biotechnology / methods Drug Industry* Plants, Genetically Modified / metabolism* Recombinant Proteins / biosynthesis* Technology, Pharmaceutical / methods Vaccines / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Recombinant Proteins; 0/Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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