| Biomonitorization of cadmium, chromium, manganese, nickel and lead in whole blood, urine, axillary hair and saliva in an occupationally exposed population. | |
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MedLine Citation:
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PMID: 21211822 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Heavy metal contamination from occupational origin is a cause for concern because of its potential accumulation in the environment and in living organisms leading to long term toxic effects. This study was aimed to assess Cd, Cr, Mn, Ni and Pb levels in whole blood, urine, axillary hair and saliva from 178 individuals with occupational exposure to heavy metals. Levels of metal compounds were determined by atomic absorption spectrometry. We collected information on occupation, lifestyle habits and food intake by questionnaire. Multiple linear regression analyses for metal ion concentration in whole blood, urine, axillary hair and saliva were adjusted for age, gender, smoking and alcohol consumption, lifetime workplace exposure, residence area and food habits. Overall, blood and urine median concentrations found for the five metals analyzed do not exceed biological exposure indexes, so that they are very similar to a non-occupationally exposed population. Toxicokinetic differences may account for the lack of correlations found for metal levels in hair and saliva with those in blood or urine. For those heavy metals showing higher median levels in blood with respect to hair (Cd, Mn and Pb) indicating lesser hair incorporation from blood, the lifetime working experience was inversely correlated with their hair levels. The longer the lifetime working experience in industrial environments, the higher the Mn and Ni concentration in saliva. Axillary hair and saliva may be used as additional and/or alternative samples to blood or urine for biomonitoring hair Mn, and saliva Ni in subjects with occupational exposure. |
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Authors:
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Fernando Gil; Antonio F Hernández; Claudia Márquez; Pedro Femia; Pablo Olmedo; Olga López-Guarnido; Antonio Pla |
Publication Detail:
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Type: Journal Article Date: 2011-01-06 |
Journal Detail:
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Title: The Science of the total environment Volume: 409 ISSN: 1879-1026 ISO Abbreviation: Sci. Total Environ. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0330500 Medline TA: Sci Total Environ Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1172-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Legal Medicine and Toxicology, University of Granada, School of Medicine, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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