Document Detail

Biomonitoring of genotoxicity using micronuclei assay in native population of Astyanax jacuhiensis (Characiformes: Characidae) at sites under petrochemical influence.
MedLine Citation:
PMID:  18715629     Owner:  NLM     Status:  MEDLINE    
Bom Jardim brook is a small stream that flows through an area under the influence of a Petrochemical Complex, demanding control over its quality, so a genotoxic evaluation was performed. This study was conducted in situ, based on previous analysis on the same subject. These were performed both in vitro, with Salmonella typhimurium and human lymphocytes, and in vivo, using bioassays with fish exposed to water from the study area. The purpose of this research was to assess the quality of the aquatic environment and possible effects from petrochemical pollution to surrounding native populations. Micronuclei (MNE) and nuclear abnormalities (NA) frequencies in peripheral blood of Astyanax jacuhiensis, a native fish species collected from the study area, were used as biomarkers. Study period was from summer/99 to spring/2001, using samples obtained seasonally at two ponds upstream from the industrial area (BJN and BJPa) and two sites in Bom Jardim brook (BJ002 and BJ000), which are subject to Complex influence. MNE and NA frequencies found in individuals from BJ002 and BJ000 were similar, showing positive genotoxic responses related to control sites BJN and BJPa. No differential sensitivity could be verified for micronuclei induction between genders of A. jacuhiensis in the studied population. This study showed that sites subject to petrochemical influence were under higher genotoxic impact. Biomarkers adequacy to the case and the sensitivity of A. jacuhiensis for water monitoring could be also inferred.
Clarice Torres de Lemos; Fábio de Almeida Iranço; Nânci Cristina D'Avila de Oliveira; Getúlio Dornelles de Souza; Jandyra Maria Guimarães Fachel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-19
Journal Detail:
Title:  The Science of the total environment     Volume:  406     ISSN:  0048-9697     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  337-43     Citation Subset:  IM    
Divisão de Biologia, Programa de Pesquisas Ambientais, Departamento de Laboratórios, Fundação Estadual de Proteção Ambiental Henrique Luís Roessler (FEPAM), Avenida Dr. Salvador França, 1707, 90690-000, Porto Alegre, RS, Brazil.
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MeSH Terms
Biological Markers / blood
Cyprinidae / blood*
Environmental Monitoring*
Micronucleus Tests / methods*
Mutagenicity Tests
Petroleum / toxicity*
Salmonella typhimurium
Time Factors
Water Pollutants, Chemical / blood,  toxicity*
Reg. No./Substance:
0/Biological Markers; 0/Petroleum; 0/Water Pollutants, Chemical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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