Document Detail


Biomonitoring of exposure to potential mutagens and carcinogens in industrial populations.
MedLine Citation:
PMID:  4038679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methods for monitoring exposure to potential industrial mutagens and carcinogens fall into two distinct groups. The tests in the first group measure the concentration of the substance, of its metabolites or of the products of its reaction with cellular macromolecules, in biological media. Such tests include the determination of urinary metabolites of the chemical, the measurement of nucleic-acid or protein adducts and the determination of urinary thioethers. The second group comprises assays of biological endpoints that may be the result of the organism's reaction to exposure. These endpoints include chromosomal aberrations in peripheral lymphocytes and sister chromatid exchanges. Each test has advantages and limitations that will affect its suitability for use in specific industrial situations.
Authors:
N J van Sittert; G de Jong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  23     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-03-29     Completed Date:  1985-03-29     Revised Date:  2006-03-13    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Benzene / adverse effects
Carcinogens, Environmental* / urine
Chromosome Aberrations / drug effects
DNA / metabolism
Environmental Exposure
Epichlorohydrin / adverse effects
Epoxy Compounds / adverse effects
Ethylene Oxide / adverse effects
Humans
Mutagens* / urine
Occupational Diseases / chemically induced
Protein Binding
Styrene
Styrenes / adverse effects
Vinyl Chloride / adverse effects
Chemical
Reg. No./Substance:
0/Carcinogens, Environmental; 0/Epoxy Compounds; 0/Mutagens; 0/Styrenes; 100-42-5/Styrene; 106-89-8/Epichlorohydrin; 71-43-2/Benzene; 75-01-4/Vinyl Chloride; 75-21-8/Ethylene Oxide; 75-56-9/propylene oxide; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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