| Biomonitoring of exposure to potential mutagens and carcinogens in industrial populations. | |
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MedLine Citation:
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PMID: 4038679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methods for monitoring exposure to potential industrial mutagens and carcinogens fall into two distinct groups. The tests in the first group measure the concentration of the substance, of its metabolites or of the products of its reaction with cellular macromolecules, in biological media. Such tests include the determination of urinary metabolites of the chemical, the measurement of nucleic-acid or protein adducts and the determination of urinary thioethers. The second group comprises assays of biological endpoints that may be the result of the organism's reaction to exposure. These endpoints include chromosomal aberrations in peripheral lymphocytes and sister chromatid exchanges. Each test has advantages and limitations that will affect its suitability for use in specific industrial situations. |
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Authors:
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N J van Sittert; G de Jong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 23 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-03-29 Completed Date: 1985-03-29 Revised Date: 2006-03-13 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 23-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzene
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adverse effects Carcinogens, Environmental* / urine Chromosome Aberrations / drug effects DNA / metabolism Environmental Exposure Epichlorohydrin / adverse effects Epoxy Compounds / adverse effects Ethylene Oxide / adverse effects Humans Mutagens* / urine Occupational Diseases / chemically induced Protein Binding Styrene Styrenes / adverse effects Vinyl Chloride / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens, Environmental; 0/Epoxy Compounds; 0/Mutagens; 0/Styrenes; 100-42-5/Styrene; 106-89-8/Epichlorohydrin; 71-43-2/Benzene; 75-01-4/Vinyl Chloride; 75-21-8/Ethylene Oxide; 75-56-9/propylene oxide; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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