Document Detail


Biomonitoring as a method for assessing exposure to perchlorate.
MedLine Citation:
PMID:  17822374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biomonitoring provides direct and quantitative information regarding human exposure to environmental toxicants, such as perchlorate (ClO(4)(-)). Because of concerns surrounding widespread exposure to ClO(4)(-), we are using biomonitoring methods to assess exposure to ClO(4)(-) and other physiologically relevant anions that can impact iodide uptake by the thyroid. These methods quantify ClO(4)(-), thiocyanate, nitrate, and iodide in human urine, milk, serum, blood spots, amniotic fluid, and infant formula using ion chromatography coupled with electrospray ionization tandem mass spectrometry. In this paper we summarize recent ClO(4)(-) biomonitoring research and provide three additional examples of the utility of biomonitoring for characterizing ClO(4)(-) exposure. Specifically, we examine variability in ClO(4)(-) excretion, compare the relative importance of different exposure sources in adults, and estimate ClO(4)(-) exposure in formula-fed infants. These applications provide examples of how biomonitoring can improve individual exposure assessment. Individual biomarker data can subsequently be compared with individual thyroid function data to better evaluate potential linkage between ClO(4)(-) exposure and health.
Authors:
Benjamin C Blount; Liza Valentín-Blasini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  17     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-24     Completed Date:  2007-11-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  837-41     Citation Subset:  IM    
Affiliation:
Division of Laboratory Sciences, National Center for Environmental Health, CDC, Atlanta, Georgia 30341, USA. bkb3@cdc.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Environmental Exposure / analysis*
Environmental Monitoring / methods*
Humans
Hypothyroidism / etiology
Infant
Infant Formula / chemistry
Perchloric Acid / adverse effects*,  urine
Spectrometry, Mass, Electrospray Ionization
Chemical
Reg. No./Substance:
0/perchlorate; 7601-90-3/Perchloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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