Document Detail


Biomonitoring Equivalents for triclosan.
MedLine Citation:
PMID:  20541577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent efforts worldwide have resulted in a growing database of measured concentrations of chemicals in blood and urine samples taken from the general population. However, few tools exist to assist in the interpretation of the measured values in a health risk context. Biomonitoring Equivalents (BEs) are defined as the concentration or range of concentrations of a chemical or its metabolite(s) in a biological medium (blood, urine, or other medium) consistent with an existing health-based exposure guideline, and are derived by integrating available data on pharmacokinetics with existing chemical risk assessments. This study reviews available health-based exposure guidance values for triclosan based on recent evaluations from the United States Environmental Protection Agency (US EPA), the European Commission's Scientific Committee on Consumer Products (EC SCCP) and the Australian National Industrial Chemicals Notification and Assessment Scheme (NICNAS). BE values corresponding to the reference dose (RfD) or margin of safety (MOS) targets from these agencies were derived based on kinetic data (urinary excretion and plasma clearance) from human studies and measured blood concentration data in animal studies. Estimated BE values for urinary total triclosan (free plus conjugates) corresponding to the US EPA RfD and the EC-identified margin of safety target from the NOAEL are 6.4 and 2.6 mg/L, respectively (corresponding to 8.3 and 3.3mg/g creatinine, respectively). Plasma BE values corresponding to the US EPA, EC, and Australian NICNAS values are 0.3, 0.9, and 0.4 mg/L, respectively. These values may be used as screening tools for evaluation of population biomonitoring data for triclosan in a risk assessment context.
Authors:
Kannan Krishnan; Michelle Gagné; Andy Nong; Lesa L Aylward; Sean M Hays
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-10
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  58     ISSN:  1096-0295     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Affiliation:
Département deSanté Environnementale et Santé au Travail, Université de Montréal, Montréal, QC, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Infective Agents, Local / metabolism,  pharmacokinetics,  standards*
Biological Markers / metabolism
Child
Environmental Exposure / standards,  statistics & numerical data
Environmental Monitoring / standards*
Environmental Pollutants / metabolism,  pharmacokinetics,  standards*
Environmental Pollution / statistics & numerical data
Female
Humans
Male
Middle Aged
Reference Values
Risk Assessment
Triclosan / metabolism,  pharmacokinetics,  standards*
Young Adult
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Biological Markers; 0/Environmental Pollutants; 3380-34-5/Triclosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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