Document Detail

Biomonitoring the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in canine fur.
MedLine Citation:
PMID:  22906298     Owner:  NLM     Status:  MEDLINE    
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine (HAA) that is formed during the cooking of meat, poultry, and fish. PhIP is a rodent carcinogen and is thought to contribute to several diet-related cancers in humans. PhIP is present in the hair of human omnivores but not in the hair of vegetarians. We have now identified PhIP in the fur of 14 out of 16 healthy dogs consuming different brands of commercial pet food. The levels of PhIP in canine fur varied by over 85-fold and were comparable to the levels of PhIP present in human hair. However, high density fur containing PhIP covers a very high proportion of the body surface area of dogs, whereas high density terminal hair primarily covers the scalp and pubis body surface area of humans. These findings signify that the exposure and bioavailability of PhIP are high in canines. A potential role for PhIP in the etiology of canine cancer should be considered.
Dan Gu; Zachary L Neuman; Jaime F Modiano; Robert J Turesky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-29
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  60     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-12     Completed Date:  2013-01-24     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9371-5     Citation Subset:  IM    
Division of Environmental Health Sciences, Wadsworth Center, NYS Department of Health, Albany, New York 12201, USA.
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MeSH Terms
Animal Feed / analysis*
Carcinogens / analysis*
Food Contamination / analysis*
Hair / chemistry*
Imidazoles / analysis*
Meat / analysis*
Grant Support
R01 CA122320/CA/NCI NIH HHS; R01 CA122320/CA/NCI NIH HHS
Reg. No./Substance:
0/Carcinogens; 0/Imidazoles; 909C6UN66T/2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

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