| Biomolecular coronas provide the biological identity of nanosized materials. | |
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MedLine Citation:
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PMID: 23212421 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The search for understanding the interactions of nanosized materials with living organisms is leading to the rapid development of key applications, including improved drug delivery by targeting nanoparticles, and resolution of the potential threat of nanotechnological devices to organisms and the environment. Unless they are specifically designed to avoid it, nanoparticles in contact with biological fluids are rapidly covered by a selected group of biomolecules to form a corona that interacts with biological systems. Here we review the basic concept of the nanoparticle corona and its structure and composition, and highlight how the properties of the corona may be linked to its biological impacts. We conclude with a critical assessment of the key problems that need to be resolved in the near future. |
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Authors:
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Marco P Monopoli; Christoffer Aberg; Anna Salvati; Kenneth A Dawson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nature nanotechnology Volume: 7 ISSN: 1748-3395 ISO Abbreviation: Nat Nanotechnol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101283273 Medline TA: Nat Nanotechnol Country: England |
Other Details:
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Languages: eng Pagination: 779-86 Citation Subset: IM |
Affiliation:
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1] Centre for BioNano Interactions, School of Chemistry and Chemical Biology, Belfield, Dublin 4, Ireland [2] Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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