Document Detail


Biomolecular coronas provide the biological identity of nanosized materials.
MedLine Citation:
PMID:  23212421     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The search for understanding the interactions of nanosized materials with living organisms is leading to the rapid development of key applications, including improved drug delivery by targeting nanoparticles, and resolution of the potential threat of nanotechnological devices to organisms and the environment. Unless they are specifically designed to avoid it, nanoparticles in contact with biological fluids are rapidly covered by a selected group of biomolecules to form a corona that interacts with biological systems. Here we review the basic concept of the nanoparticle corona and its structure and composition, and highlight how the properties of the corona may be linked to its biological impacts. We conclude with a critical assessment of the key problems that need to be resolved in the near future.
Authors:
Marco P Monopoli; Christoffer Aberg; Anna Salvati; Kenneth A Dawson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature nanotechnology     Volume:  7     ISSN:  1748-3395     ISO Abbreviation:  Nat Nanotechnol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101283273     Medline TA:  Nat Nanotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  779-86     Citation Subset:  IM    
Affiliation:
1] Centre for BioNano Interactions, School of Chemistry and Chemical Biology, Belfield, Dublin 4, Ireland [2] Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
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