| Biomodulative effects of visible and IR laser light on the healing of cutaneous wounds of nourished and undernourished Wistar rats. | |
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MedLine Citation:
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PMID: 19821705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: We evaluated histologically the differences in the healing of cutaneous wounds on nourished or undernourished rats following laser phototherapy (LPT) (20 or 40 J/cm2). BACKGROUND: Wound healing occurs due to a competitive mechanism between the synthesis and lysis of collagen. Any factor that increases the lysis or reduces the synthesis of collagen may change the healing process. Nutritional deficiencies have a great effect on wound healing. METHODS: Fifty nourished or undernourished Wistar rats had one standardized wound created on the dorsum and were divided into 10 subgroups: Control (standard diet); Control [Northeastern Brazilian basic diet (DBR)]; Standard diet+LPT (lambda635 nm; spatial average energy fluence (SAEF) 20 J/cm2); Standard diet+LPT (lambda635 nm; SAEF 40 J/cm2); Standard diet+LPT (lambda780 nm; SAEF 20 J/cm2); Standard diet+LPT (lambda780 nm; SAEF 40 J/cm2); DBR+LPT (lambda635 nm; SAEF 20 J/cm2); DBR+LPT (lambda635 nm; SAEF 40 J/cm2); DBR+LPT (lambda780 nm; SAEF 20 J/cm2); DBR+LPT (lambda780 nm; SAEF 40 J/cm2). The first application of the treatment was carried out immediately and repeated daily for seven days. The specimens were routinely processed to wax, cut, stained with H&E and Sirius Red stains, and analyzed using light microscopy. The analyses included re-epithelization, inflammatory infiltrate, and fibroblastic proliferation. Sirius Red stained slides were used to perform descriptive analyses of the collagen fibers. RESULTS: The results showed that LPT with lambda635 wavelength was more effective for the treatment of undernourished subjects, treated with either LPT with lambda730 nm with SAEF of 20 J/cm2 or lambda780 nm with SAEF of 40 J/cm2. CONCLUSION: Nutritional status influenced the progression of the healing process as well as the quality of the healed tissue. In addition, the use of both wavelengths resulted in a positive biomodulatory effect on both nourished and undernourished subjects. |
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Authors:
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Antonio Luiz Barbosa Pinheiro; Gyselle Cynthia Silva Meireles; Carolina Montagn Carvalho; Luciana Maria Pedreira Ramalho; Jean Nunes dos Santos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Photomedicine and laser surgery Volume: 27 ISSN: 1557-8550 ISO Abbreviation: Photomed Laser Surg Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-28 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101222340 Medline TA: Photomed Laser Surg Country: United States |
Other Details:
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Languages: eng Pagination: 947-57 Citation Subset: IM |
Affiliation:
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Laser Center, Department of Propedeutica and Clinical Integrada, School of Dentistry, Federal University of Bahia, Salvador, BA, Brazil. albp@ufba.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Laser Therapy / methods Malnutrition / physiopathology* Nutritional Status Photomicrography Phototherapy / methods* Rats Rats, Wistar Skin / injuries*, radiation effects Staining and Labeling Wound Healing / radiation effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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