Document Detail

Biomimetic scaffolds: implications for craniofacial regeneration.
MedLine Citation:
PMID:  22337428     Owner:  NLM     Status:  MEDLINE    
With the advancement in stem cell research and material science, tissue regeneration has been evolved from scientific hypothesis to clinical reality and thus will have a great potential in regenerating craniofacial tissue. In this approach, scaffold plays an essential role in tissue regeneration by recruiting host regenerative cells or enhancing adhesion, proliferation and matrix production of seeded cells, and eventual formation of the desired tissue type. Moreover, incorporation of biomimesis concept into scaffold design and manufacture will further enhance the quality and function of regenerated tissues. This article summarizes new developments of biomimetic scaffolds including the biomimesis of extracellular matrix, cell-matrix interaction, and tissue-regenerative signaling.
Jie Yuan; Yilin Cao; Wei Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of craniofacial surgery     Volume:  23     ISSN:  1536-3732     ISO Abbreviation:  J Craniofac Surg     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-16     Completed Date:  2012-07-24     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  9010410     Medline TA:  J Craniofac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  294-7     Citation Subset:  D    
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Tissue Engineering Key Laboratory, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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MeSH Terms
Amino Acid Sequence
Biomimetic Materials / chemistry*
Bone Marrow Cells / physiology
Bone Matrix / physiology
Bone Regeneration / physiology*
Bone Substitutes / chemistry
Calcium Phosphates / chemistry
Cell Adhesion / physiology
Cell Differentiation / physiology
Cell Proliferation
Cell-Matrix Junctions / physiology
Chitosan / chemistry
Collagen / chemistry
Durapatite / chemistry
Extracellular Matrix / physiology
Facial Bones / surgery*
Intercellular Signaling Peptides and Proteins / therapeutic use
Oligopeptides / chemistry
Osteogenesis / physiology
Reconstructive Surgical Procedures / methods*
Signal Transduction / physiology
Skull / surgery*
Stromal Cells / physiology
Surface Properties
Tissue Engineering / methods*
Tissue Scaffolds*
Reg. No./Substance:
0/Bone Substitutes; 0/Calcium Phosphates; 0/Intercellular Signaling Peptides and Proteins; 0/Oligopeptides; 1306-06-5/Durapatite; 9007-34-5/Collagen; 9012-76-4/Chitosan; 97Z1WI3NDX/calcium phosphate; 99896-85-2/arginyl-glycyl-aspartic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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