Document Detail

Biomechanopharmacology: a new borderline discipline.
MedLine Citation:
PMID:  16678914     Owner:  NLM     Status:  MEDLINE    
Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized.
Fulong Liao; Min Li; Dong Han; Jun Cao; Keji Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-06
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  27     ISSN:  0165-6147     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  287-9     Citation Subset:  IM    
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
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MeSH Terms
Biomechanics / trends*
Blood Circulation / drug effects,  physiology
Drugs, Chinese Herbal / pharmacology
Exercise / physiology
Pharmacology / trends*
Platelet Aggregation Inhibitors / pharmacology
Stress, Mechanical
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Platelet Aggregation Inhibitors

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