| Biomechanopharmacology: a new borderline discipline. | |
MedLine Citation:
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PMID: 16678914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Flowing blood is more than a drug transporter in pharmacology; its mechanical impact should also be considered. The in vitro pharmacological dose-response pattern of endothelial cellular functions can be significantly modified by in vivo shear stress. A new borderline discipline, biomechanopharmacology, is forming at the boundary between biomechanics and pharmacology. Biomechanopharmacology will probably consist of both the pharmacological intervention of signals induced by biomechanical factors and the biomechanical influence on pharmacokinetics and pharmacodynamics, in addition to the joint effect of biomechanical and pharmacological factors. Recent investigations show that exercise enhances the shear of pulsatile blood flow to stimulate angiogenesis. The benefits of exercise for gaining joint biomechanical and pharmacological effects should be emphasized. |
Authors:
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Fulong Liao; Min Li; Dong Han; Jun Cao; Keji Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-05-06 |
Journal Detail:
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Title: Trends in pharmacological sciences Volume: 27 ISSN: 0165-6147 ISO Abbreviation: Trends Pharmacol. Sci. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-13 Completed Date: 2006-10-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906158 Medline TA: Trends Pharmacol Sci Country: England |
Other Details:
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Languages: eng Pagination: 287-9 Citation Subset: IM |
Affiliation:
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Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China. liaofulong100@yahoo.com.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics
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trends* Blood Circulation / drug effects, physiology Drugs, Chinese Herbal / pharmacology Exercise / physiology Humans Pharmacology / trends* Platelet Aggregation Inhibitors / pharmacology Stress, Mechanical |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/Platelet Aggregation Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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