| Biomechanics of the esophagogastric junction in gastroesophageal reflux disease. | |
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MedLine Citation:
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PMID: 18625134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastroesophageal reflux is inherently mechanical in nature, driven by the pressure difference between the stomach and the esophagus in the setting of a relaxed or hypotensive sphincter. Recent advances in our understanding of esophagogastric junction (EGJ) biomechanics in the etiology of gastroesophageal reflux disease are highlighted here. We focus this review on three critical areas: the anatomy and physiology of the EGJ that predispose the junction to reflux, the mechanical compliance of the EGJ musculature that has significant pathophysiologic underpinnings, and the trans-sphincteric pressure gradients during gastroesophageal reflux. We also examine the mechanistic basis of a higher incidence of reflux in obese patients and conclude with some observations on the future of understanding EGJ biomechanics. |
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Authors:
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Sudip K Ghosh |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current gastroenterology reports Volume: 10 ISSN: 1534-312X ISO Abbreviation: Curr Gastroenterol Rep Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-15 Completed Date: 2008-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888896 Medline TA: Curr Gastroenterol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 246-51 Citation Subset: IM |
Affiliation:
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Division of Digestive Diseases, Academic Health Center, University of Cincinnati, 231 Albert Sabin Way, ML 0595, Cincinnati, OH 45267, USA. sudip.k.ghosh@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Esophagogastric Junction / physiopathology* Gastroesophageal Reflux / etiology, physiopathology* Humans Obesity / complications, physiopathology Pressure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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