Document Detail


Biomechanics of the sensor-tissue interface-effects of motion, pressure, and design on sensor performance and foreign body response-part II: examples and application.
MedLine Citation:
PMID:  21722579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article is the second part of a two-part review in which we explore the biomechanics of the sensor-tissue interface as an important aspect of continuous glucose sensor biocompatibility. Part I, featured in this issue of Journal of Diabetes Science and Technology, describes a theoretical framework of how biomechanical factors such as motion and pressure (typically micromotion and micropressure) affect tissue physiology around a sensor and in turn, impact sensor performance. Here in Part II, a literature review is presented that summarizes examples of motion or pressure affecting sensor performance. Data are presented that show how both acute and chronic forces can impact continuous glucose monitor signals. Also presented are potential strategies for countering the ill effects of motion and pressure on glucose sensors. Improved engineering and optimized chemical biocompatibility have advanced sensor design and function, but we believe that mechanical biocompatibility, a rarely considered factor, must also be optimized in order to achieve an accurate, long-term, implantable sensor.
Authors:
Kristen L Helton; Buddy D Ratner; Natalie A Wisniewski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-05-01
Journal Detail:
Title:  Journal of diabetes science and technology     Volume:  5     ISSN:  1932-2968     ISO Abbreviation:  J Diabetes Sci Technol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2012-03-25     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101306166     Medline TA:  J Diabetes Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  647-56     Citation Subset:  IM    
Copyright Information:
© 2011 Diabetes Technology Society.
Affiliation:
University of Washington, Seattle, Washington, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials
Biomechanics
Blood Glucose / analysis*
Blood Glucose Self-Monitoring / methods*
Diabetes Mellitus / diagnosis*,  metabolism
Dogs
Equipment Design
Glucose
Humans
Motion
Porosity
Pressure
Rats
Reproducibility of Results
Self Care
Swine
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Blood Glucose; 50-99-7/Glucose
Comments/Corrections

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