Document Detail


Biomechanics of the chick embryonic heart outflow tract at HH18 using 4D optical coherence tomography imaging and computational modeling.
MedLine Citation:
PMID:  22844414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During developmental stages, biomechanical stimuli on cardiac cells modulate genetic programs, and deviations from normal stimuli can lead to cardiac defects. Therefore, it is important to characterize normal cardiac biomechanical stimuli during early developmental stages. Using the chicken embryo model of cardiac development, we focused on characterizing biomechanical stimuli on the Hamburger-Hamilton (HH) 18 chick cardiac outflow tract (OFT), the distal portion of the heart from which a large portion of defects observed in humans originate. To characterize biomechanical stimuli in the OFT, we used a combination of in vivo optical coherence tomography (OCT) imaging, physiological measurements and computational fluid dynamics (CFD) modeling. We found that, at HH18, the proximal portion of the OFT wall undergoes larger circumferential strains than its distal portion, while the distal portion of the OFT wall undergoes larger wall stresses. Maximal wall shear stresses were generally found on the surface of endocardial cushions, which are protrusions of extracellular matrix onto the OFT lumen that later during development give rise to cardiac septa and valves. The non-uniform spatial and temporal distributions of stresses and strains in the OFT walls provide biomechanical cues to cardiac cells that likely aid in the extensive differential growth and remodeling patterns observed during normal development.
Authors:
Aiping Liu; Xin Yin; Liang Shi; Peng Li; Kent L Thornburg; Ruikang Wang; Sandra Rugonyi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-07-23
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-11-28     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e40869     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Blood Circulation
Blood Flow Velocity
Blood Pressure
Chick Embryo
Computer Simulation*
Endocardium / metabolism
Heart / physiology*
Mechanical Processes*
Movement
Myocardium / metabolism
Stress, Mechanical
Time Factors
Tomography, Optical Coherence*
Uncertainty
Grant Support
ID/Acronym/Agency:
HL094570/HL/NHLBI NIH HHS; R01 HL094570/HL/NHLBI NIH HHS
Comments/Corrections

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