| Biomechanical signals in the coronary artery triggering the metabolic processes during cardiac overload. | |
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MedLine Citation:
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PMID: 7494557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peculiarities in structure and deformability of epicardial conduit coronary arteries are described. The thin wall of animal coronary artery contrasts the human coronary artery in which the remarkable wall thickness is due namely by the intima thickness. Deformation in length and diameter of conduit coronary arteries, due to the left and right ventricle volume increase, has been defined in non-beating canine heart. Ramus interventricularis anterior being firmly tethered to the myocardium undergoes about 3 times larger deformation than ramus circumflexus. In anaesthetized dogs a 30% increase in blood pressure, elicited by aortic constriction, induces an increase in diameter of coronary artery, in segment length, in blood flow and consequently in shear stress which represents a load for circumferentially running smooth muscle bundles, longitudinally running smooth muscle bundles, as well as for the endothelium. The above load lasting 4 h is already reflected by an increase in total RNA content and [14C] leucin incorporation in the left ventricle myocardium in the wall of ramus interventricularis anterior, not in ramus circumflexus. The findings fit completely with the different range of deformation of both the above coronary branches and indicates an increase in proteosynthesis not only in myocardium, but in ramus interventricularis anterior as well. An increase in ornithindecarboxylase activity in coronary wall leading to an increase in biogenic polyamines, is present in the case only, when blood pressure increase is induced by infusion of noradrenaline. |
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Authors:
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M Gerová; O Pechánová; V Stoev; M Kittová; I Bernátová; M Juráni; S Dolezel |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 147 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 1995 Jun 7-21 |
Date Detail:
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Created Date: 1996-01-11 Completed Date: 1996-01-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 69-73 Citation Subset: IM; S |
Affiliation:
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Department of Physiology, Medical School, Comenius University; Bratislava, Slovakia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / physiology Blood Pressure* Coronary Circulation Coronary Vessels / physiology* Dogs Leucine / metabolism Muscle, Smooth, Vascular / physiology Myocardium / metabolism* Ornithine Decarboxylase / metabolism Protein Biosynthesis* RNA / metabolism Stress, Mechanical Tunica Intima / physiology Ventricular Function, Left / physiology |
| Chemical | |
Reg. No./Substance:
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61-90-5/Leucine; 63231-63-0/RNA; EC 4.1.1.17/Ornithine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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