Document Detail


Biomechanical properties of human and porcine corneas.
MedLine Citation:
PMID:  18396276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The suitability of porcine corneas as approximate models for human corneas in mechanical property characterisation studies is experimentally assessed. Thirty seven human donor corneas and thirty four ex-vivo porcine corneas were tested under inflation conditions to determine their short-term stress-strain behaviour and long-term creep behaviour up to 2.8 h (10,000 s). Vertical strips extracted from further 12 human corneas and 10 porcine corneas were subjected to stress-relaxation tests for up to 20 min at different stress levels. Human and porcine corneas were observed to have almost the same form of behaviour under short and long-term loading. They both exhibited non-linear stress-strain behaviour and reacted to sustained loading in a similar fashion. However, human corneas were significantly stiffer than porcine corneas. They also crept less under long-term loading and could sustain their stress state for longer compared to porcine corneas. These differences, in addition to others identified earlier in relation to corneal mechanical anisotropy, cast doubt on the suitability of porcine corneas as models for human corneas in mechanical studies.
Authors:
Ahmed Elsheikh; Daad Alhasso; Paolo Rama
Related Documents :
1308876 - Ultrastructural analysis of the adaptation of articular cartilage to mechanical stimula...
21614106 - Controlling light transport by using a graded photonic crystal.
8851536 - Trunk kinematics of one-handed lifting, and the effects of asymmetry and load weight.
2619836 - A study of the cracking sounds from the metacarpophalangeal joint.
20821606 - Dual enantioselective effect of the insecticide bifenthrin on locomotor behavior and de...
22789996 - Action sounds recalibrate perceived tactile distance.
Publication Detail:
Type:  Journal Article     Date:  2008-03-04
Journal Detail:
Title:  Experimental eye research     Volume:  86     ISSN:  0014-4835     ISO Abbreviation:  Exp. Eye Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370707     Medline TA:  Exp Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  783-90     Citation Subset:  IM    
Affiliation:
Division of Civil Engineering, University of Dundee, Dundee DD1 4HN, UK. a.i.h.elsheikh@dundee.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aging / physiology
Animals
Biomechanics
Cornea / physiology*
Elasticity
Humans
Middle Aged
Models, Animal
Models, Biological
Pressure
Species Specificity
Stress, Mechanical
Sus scrofa / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Structural requirements for the assembly of LINC complexes and their function in cellular mechanical...
Next Document:  Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of le...