| Biomechanical properties of skin in massive weight loss patients. | |
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MedLine Citation:
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PMID: 20401759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study is to assess skin strength in MWL patients relative to control cosmetic abdominoplasty patients biophysically, biochemically, and histologically. Growing success of weight loss programs has brought about an increase in the MWL population. Skin quality is thought to be impaired by MWL, but there are no compelling studies that have fully addressed the structural mechanisms involved. METHODS: Skin from the medial and lateral abdomen was harvested fresh from patients undergoing cosmetic abdominoplasty (n = 6) or abdominal panniculectomy for MWL (n = 35), and burst strength was tested in the horizontal and vertical directions. Collagen content was measured, and histological studies were performed to assess epidermal and dermal thickness, vascularity as well as the morphology and density of the collagen fibers. RESULTS: In all groups, skin stretched horizontally was stronger than skin stretched vertically (p < 0.001). The skin of MWL patients was stronger medially compared to the skin of cosmetic patients. (p = 0.047) Newly formed collagen was diminished in MWL than that in the control group, but the results were not statistically significant. Epidermal thickness was significantly higher medially in MWL (p = 0.049). Elastin fibers were decreased in the MWL group, while dermal vascularity was higher in the MWL group. CONCLUSIONS: The skin of MWL patients demonstrated stronger mechanical parameters than that of cosmetic patients in the medial part of the abdomen; however, the decrease in elastic fibers associated with a decrease in newly formed collagen seemingly provides a contradiction. Skin changes with MWL merits further study to understand it more completely. |
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Authors:
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Shelly Choo; Guy Marti; Manuel Nastai; Jessie Mallalieu; Michele A Shermak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obesity surgery Volume: 20 ISSN: 1708-0428 ISO Abbreviation: Obes Surg Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106714 Medline TA: Obes Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1422-8 Citation Subset: IM |
Affiliation:
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The Johns Hopkins Medical Institutions, Division of Plastic Surgery, 4940 Eastern Ave, Baltimore, MD 21224, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen Biomechanics Collagen / metabolism Elastic Tissue / pathology Elasticity Gastric Bypass Humans Immunohistochemistry Obesity, Morbid / pathology, physiopathology*, surgery Skin* / metabolism, pathology Weight Loss / physiology* |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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