| Biomechanical Behavior of a Biomimetic Artificial Intervertebral Disc. | |
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MedLine Citation:
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PMID: 21912317 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: Study Design: The biomechanical behavior of a biomimetic artificial intervertebral disc (AID) was characterized in vitro in axial compression, and compared to natural disc behavior.Objective: To evaluate the strength and durability of a novel biomimetic AID and to demonstrate whether its axial deformation behavior is similar to that of a natural disc.Summary of Background Data: Current clinically used AIDs have reasonable success rates. However, due to their non-physiological design, spinal mechanics is altered. In order to avoid long-term complications, a novel biomimetic AID, with a nucleus-annulus structure, and osmotic swelling properties has been developed.Methods: 18 AIDs in total were tested in axial compression. Six were loaded monotonically to determine strength. Six were tested in fatigue (600-6000 N). Another six were used to characterize the axial creep and dynamic behavior (0.01 to 10 Hz). Creep and dynamic response were also determined for four AIDs after fatigue loading.Results: The AIDs remained intact up to 15kN, and 10 million cycles. The creep and dynamic behavior was similar to the natural disc behavior, except for hysteresis which was 20-30% higher. After fatigue, creep decreased from 4% to 1%, stiffness increase two-fold, and hysteresis was reduced to that for a normal disc.Conclusions: A strong and durable AID design was introduced. Compared to current clinical articulating AIDs, this biomimetic AID introduces the natural disc annulus-nucleus structure, resulting in axial behavior closer to that of the natural disc. |
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Authors:
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Peter R van den Broek; Jacques M Huyghe; Keita Ito |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-8 |
Journal Detail:
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Title: Spine Volume: - ISSN: 1528-1159 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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