Document Detail

Biomechanical assessment of the individual risk of rupture of cerebral aneurysms: a proof of concept.
MedLine Citation:
PMID:  22864824     Owner:  NLM     Status:  MEDLINE    
This study is a step towards a new biomechanical-based measurement of the patient specific risk of rupture of cerebral aneurysms. Following a previous experimental investigation suggesting a correlation between the risk of rupture and the material properties of cerebral aneurysms, fluid-structure interaction simulations are performed to compare the deformations of a patient-specific aneurysm when using degraded or undegraded materials. Results show that material properties have a major impact on the magnitude of systolic/diastolic aneurysmal volume variations along the cardiac cycle. Changes in terms of aneurysmal volume variations depending on the tissue characteristics are shown to be measurable by medical imaging. A one-at-a-time data uncertainty analysis is also presented and shows the robustness of this result to input data uncertainties. The study thus suggests that aneurysmal volume variations may be used as the basis of a biomechanical index of rupture risk.
M Sanchez; D Ambard; V Costalat; S Mendez; F Jourdan; F Nicoud
Related Documents :
18971564 - Locations of coronary artery lesions in patients with severe conduction disturbance.
20730074 - Using noncontrast cardiac ct and coronary artery calcification measurements for cardiov...
201264 - Emc viral infection of the coronary blood vessels in newborn mice: viral vasculitis.
20427414 - The relationship between coronary slow flow phenomenon and coronary calcium score.
1122364 - Traumatic haemobilia.
12919984 - Ultrasonic locating devices for central venous cannulation: meta-analysis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-03
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  41     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-05-28     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-40     Citation Subset:  IM    
Philips Healthcare, 33 rue de Verdun, 92150, Suresnes Cedex, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aneurysm, Ruptured / physiopathology*
Arteries / physiopathology
Intracranial Aneurysm / physiopathology*
Intracranial Pressure
Models, Biological*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Piezoelectric substrates promote neurite growth in rat spinal cord neurons.
Next Document:  Photoluminescence from Bi(5)(GaCl(4))(3) molecular crystal.