Document Detail

Biomarkers of xenobiotic exposures.
MedLine Citation:
PMID:  3044268     Owner:  NLM     Status:  MEDLINE    
Direct measurement of xenobiotic (foreign) chemicals is not always feasible as an exposure assessment,--owing to rapid metabolism, sequestration into fatty tissues, or lack of suitable assay methods. Furthermore, suspect exposures often involve complex mixtures of organics. In these circumstances, indirect biomarkers of exposure can be most helpful. This paper reviews four urinary parameters that hold promise as biomarkers of exposure in occupational and environmental settings: glucaric acid (end-product of the glucuronidation pathway), thioethers (end-product of glutathione reaction with electrophilic or alkylating agents), porphyrin pattern (altered with disruption in heme biosynthesis), and the Ames mutagenicity test.
M A Brewster
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  18     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1988-09-21     Completed Date:  1988-09-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  306-17     Citation Subset:  IM    
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
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MeSH Terms
Chemical Industry
Environmental Exposure*
Glucaric Acid / urine
Mutagenicity Tests
Occupational Medicine*
Pharmaceutical Preparations / urine*
Sulfides / urine
Reg. No./Substance:
0/Pharmaceutical Preparations; 0/Sulfides; 25525-21-7/Glucaric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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