| Biomarkers of xenobiotic exposures. | |
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MedLine Citation:
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PMID: 3044268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Direct measurement of xenobiotic (foreign) chemicals is not always feasible as an exposure assessment,--owing to rapid metabolism, sequestration into fatty tissues, or lack of suitable assay methods. Furthermore, suspect exposures often involve complex mixtures of organics. In these circumstances, indirect biomarkers of exposure can be most helpful. This paper reviews four urinary parameters that hold promise as biomarkers of exposure in occupational and environmental settings: glucaric acid (end-product of the glucuronidation pathway), thioethers (end-product of glutathione reaction with electrophilic or alkylating agents), porphyrin pattern (altered with disruption in heme biosynthesis), and the Ames mutagenicity test. |
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Authors:
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M A Brewster |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of clinical and laboratory science Volume: 18 ISSN: 0091-7370 ISO Abbreviation: Ann. Clin. Lab. Sci. Publication Date: 1988 Jul-Aug |
Date Detail:
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Created Date: 1988-09-21 Completed Date: 1988-09-21 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0410247 Medline TA: Ann Clin Lab Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 306-17 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Arkansas for Medical Sciences, Little Rock. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemical Industry Environmental Exposure* Glucaric Acid / urine Humans Mutagenicity Tests Occupational Medicine* Pharmaceutical Preparations / urine* Sulfides / urine |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations; 0/Sulfides; 25525-21-7/Glucaric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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